What Is VITARAN Made Of? A Complete Guide to Salmon-Trout-Derived Polynucleotides (PN)

VITARAN Skin Therapy is a polynucleotide (PN)-based product manufactured by BR PHARM in South Korea. This guide explains its principal ingredient, the source material identified by the manufacturer, what a 2% PN concentration means, and how to assess product information when comparing PN-based treatments.

What Is VITARAN Made Of?

VITARAN Skin Therapy is a professional polynucleotide (PN) product manufactured by BR PHARM, a South Korean pharmaceutical and medical-device company. Its principal ingredient is sodium polynucleotide derived from Oncorhynchus mykiss , commonly known as rainbow trout or salmon trout.

According to BR PHARM, its polynucleotide raw material is extracted from the reproductive tissue of farmed Oncorhynchus mykiss . The company describes its source material and extraction technology as part of its approach to producing purified polynucleotides for medical applications. See BR PHARM's official VITARAN product information .

The HP VITARAN product page lists its composition as 20 mg/mL of sodium polynucleotide, equivalent to 2% weight per volume (w/v). Other products, including HP VITARAN i and HP VITARAN S, are also listed in the manufacturer's portfolio; exact specifications should be checked for the particular variant. See the official pages for HP VITARAN and HP VITARAN i .

Understanding what VITARAN is made of involves more than knowing that its ingredient comes from fish. Its source material, purification process, final formulation and intended use all contribute to its product identity.

What are the main ingredients in VITARAN?

Important: This table describes the principal ingredient and published specifications, not a complete excipient list. Refer to the official instructions for use and product labelling for the full composition of the relevant VITARAN variant.

Is VITARAN made from salmon or trout?

VITARAN's source is Oncorhynchus mykiss , a species commonly known as rainbow trout or salmon trout. Although the names can cause confusion, they refer to the same species in this context.

BR PHARM states that it extracts its DNA-derived raw material from this species raised at its own farms. The ingredient in the finished product is processed polynucleotide material, rather than unprocessed fish tissue.

Why Does VITARAN Use Farmed Rainbow Trout?

According to BR PHARM, the company uses farmed Oncorhynchus mykiss as its source material and emphasises traceability and control of the raw-material supply chain.

The quality of a DNA-derived ingredient can depend on several factors, including source material, extraction method, purification process and manufacturing controls. The manufacturer's stated approach includes:

1. Source traceability: Identifying the species used as the starting material.
2. Controlled sourcing: Managing the source material through the company's production process.
3. Purification: Processing extracted DNA-derived material to obtain polynucleotides suitable for the intended product.
4. Manufacturing quality controls: Applying product-specific quality requirements during production.

BR PHARM also describes proprietary extraction technology as part of its manufacturing approach. These details help explain the manufacturer's process, but claims that a particular source or extraction method produces higher purity or better clinical outcomes than competing products require supporting analytical data and appropriate comparative evidence.

What Does 2% PN Mean in VITARAN?

Ingredient concentration describes how much of a substance is present in a given volume of solution. For HP VITARAN, BR PHARM lists a sodium polynucleotide concentration of 20 mg/mL.

• 20 mg of PN in 1 mL of solution.
• 2,000 mg of PN in 100 mL of solution.
• Therefore, 20 mg/mL is equivalent to 2% weight per volume.

A concentration of 2% describes the amount of polynucleotide in the formulation. It does not, by itself, establish how effective a product is compared with another PN treatment. Molecular characteristics, formulation properties, intended application and available clinical evidence are also relevant when evaluating a product.

How Do Polynucleotides Work?

Polynucleotides are chains of nucleotides, the basic building blocks of DNA. In aesthetic medicine, PN-based products are studied for their potential interactions with processes involved in tissue repair and dermal remodelling. The proposed mechanisms below should be understood as areas of research, not guaranteed outcomes for an individual product or patient.

Hydration and structural support

Polynucleotides are hydrophilic, meaning they interact with water. Depending on their molecular characteristics and formulation, they may contribute to a hydrated, viscoelastic environment within treated tissue. Researchers have investigated whether these physical properties can provide a supportive environment for cells and the surrounding extracellular matrix.

Interaction with tissue-repair pathways

PN and related DNA-derived materials have been studied for potential effects on biological signalling associated with tissue repair, inflammation and cellular recovery. Some proposed mechanisms involve nucleotide metabolism and signalling pathways associated with adenosine receptors. The extent to which these mechanisms translate into clinical outcomes depends on the product, dose, application and available evidence.

Fibroblasts and dermal remodelling

Fibroblasts are cells that help maintain the skin's dermal structure by producing collagen and other extracellular-matrix components. PN treatments are investigated for their potential to support the tissue environment involved in dermal remodelling. Polynucleotides are not collagen themselves, and claims about production of specific collagen types require direct supporting evidence.

In summary: VITARAN's principal ingredient is PN, a DNA-derived material. Its proposed role in skin therapy relates to interactions with the tissue environment rather than simply supplying collagen as a finished ingredient.

What Is the Difference Between PN and PDRN?

PN stands for polynucleotides, while PDRN stands for polydeoxyribonucleotide. Both are DNA-derived materials, and the terms are sometimes used inconsistently across scientific publications and product marketing.

A commonly discussed distinction is molecular size. PN formulations are often associated with longer DNA chains, while some PDRN preparations contain shorter fragments. However, terminology and molecular-weight distributions can overlap, so the names alone do not reliably establish the precise characteristics of every product.

BR PHARM describes its polynucleotide raw materials as products of its extraction and molecular-weight purification technology. The actual molecular characteristics of an individual VITARAN product should be verified against relevant technical documentation. It is not scientifically appropriate to conclude that all PN products are more effective than all PDRN products simply because of their names or presumed chain lengths.

What Is the Difference Between VITARAN, REJURAN and PLINEST?

VITARAN, REJURAN and PLINEST are brands associated with DNA-derived ingredients used in medical or aesthetic applications. Their products should be compared using their individual specifications rather than assuming that all products within each brand have identical compositions.

Manufacturer sources: BR PHARM , REJURAN Singapore and Mastelli Aesthetic Medicine .

Does VITARAN have a different raw-material source?

BR PHARM identifies farmed Oncorhynchus mykiss as the source of its polynucleotides. This is a useful factual detail when explaining VITARAN's manufacturing approach. However, source material alone does not establish that one product is safer, purer or more effective than another. Such conclusions require appropriate comparative evidence.

Does VITARAN have a different concentration?

The manufacturer lists HP VITARAN at 20 mg/mL. Comparisons with other products should use verified concentrations expressed in the same units and distinguish concentration from total content per syringe or package. For example, a product containing 40 mg in 2 mL also has a concentration of 20 mg/mL.

What should consumers look at when comparing PN products?

1. The exact ingredient and concentration.
2. The source material and manufacturing process.
3. The product's intended purpose and regulatory status.
4. Product-specific clinical evidence.
5. The formulation and instructions for use.

This approach helps distinguish verifiable product specifications from general marketing statements.

What Makes the VITARAN Range Different From Other PN Products?

BR PHARM highlights several aspects of its VITARAN manufacturing approach, including farmed rainbow-trout source material, traceability and extraction technology. These details help explain the product's identity and manufacturing rationale. The clinical importance of each feature, however, should be evaluated separately.

For example, the manufacturer has described efforts to optimise formulation properties associated with injection comfort. Any numerical claim about reduced pain, redness or other reactions should be supported by appropriate clinical data and checked against applicable product information before being used in public-facing advertising.

Similarly, descriptions such as high purity should be supported by defined analytical criteria and suitable evidence. Purity is a measurable product characteristic, not a guarantee that an individual will experience no adverse reactions.

The most accurate way to describe VITARAN is to explain what its manufacturer documents about the ingredient, concentration, source and formulation without promising a particular outcome.

What Are the HP VITARAN Product Variants?

BR PHARM lists HP VITARAN, HP VITARAN i and HP VITARAN S within its product portfolio. The names identify different products in the range, but their individual specifications and intended uses should be checked separately.

The manufacturer lists sodium polynucleotide at 20 mg/mL for HP VITARAN and HP Cell VITARAN i. Consult the applicable product instructions for other variants and markets. Although the variants are associated with the same ingredient category, they should not automatically be assumed to be identical in every formulation characteristic or intended use.

A qualified healthcare professional should select a product based on its official instructions, the individual's circumstances and the clinical assessment.

Frequently Asked Questions About VITARAN Ingredients

Conclusion: Understanding What VITARAN Is Made Of

VITARAN is a polynucleotide-based product manufactured by BR PHARM. Its principal ingredient is sodium polynucleotide derived from Oncorhynchus mykiss , commonly known as rainbow trout or salmon trout.

The manufacturer's published specifications list HP VITARAN at 20 mg/mL of sodium polynucleotide. BR PHARM also highlights its approach to raw-material sourcing, traceability and extraction technology.

For anyone researching what VITARAN is made of, the key points are the identity of the PN ingredient, its source material, its concentration and the specifications of the individual product variant. Understanding these details provides a more reliable basis for evaluating VITARAN than relying on general statements about salmon DNA or assuming that all polynucleotide products are the same.